Osaka Koi no Uta and Releasing hormone

"Osaka Koi no Uta" (大阪 恋の歌?, "Osaka Love Song") was the twenty-sixth single of J-pop idol group Morning Musume, from the group's seventh album Rainbow 7. It was released on April 27, 2005 under the Zetima label, and went on to sell a total of 59,287 copies. The single reached a peak of #2 on the weekly Oricon chart, charting for five weeks. The Single V, released on the same day, went on to sell a total of 30,324 copies. The Single V reached a peak of #6 on the weekly Oricon chart, charting for four weeks.

Contents 1 History 2 Track listings 3 Charts 3.1 CD 3.2 Single V DVD 4 Personnel 5 Members at time of single 6 References 7 External links

History

The limited edition of the single came in special packaging, and both the limited and first press of the normal edition came with photocards featuring members of the group (the limited edition containing five cards, while the normal edition only contained one). Buyers of the single or Single V were given the opportunity to send in a form to be eligible for a chance to receive a special 8 cm CD (limited to 10,000 copies) containing Ishikawa's comments on her graduation.

The titular song is sung in Osaka-ben. Producer Tsunku wrote all lyrics on the single and composed both songs, with arrangement by Hideyuki "Daichi" Suzuki and Yuichi Takahashi. The song's lyrics are meant to sound and mean different things in different languages. As producer, Tsunku asked the girls to study about Osaka in preparation for the single. The coupling song, "Nature is Good!", was used as the theme and image song for the Asahi Broadcasting Corporation's programme "Gurasu no Chikyū o Sukue" (ガラスの地球を救え, Save the Glass Planet?) between April and June 2005.

This was the first single since the departure of the final founding member, Kaori Iida, and the last single to feature Rika Ishikawa, who graduated to focus on her activities within V-u-den. This was also Mari Yaguchi's last single with the group, prior to her shock immediate departure two weeks before the release of the single, due to a scandal she was involved in. The CD artwork does, however, still feature Yaguchi, as does the music video.

The song was covered by Tsunku on his album Type 2. Member Ai Takahashi performed a solo version of the song at Morning Musume's spring 2006 concert. Track listings

All songs written and composed by Tsunku.  Charts CD Single V DVD Personnel Track 1 Atsuko Inaba (chorus) Tsunku (chorus) Hideyuki "Daichi" Suzuki (programming, guitar, arrangement) Track 2 Yuichi Takahashi (arrangement) Members at time of single 2nd generation: Mari Yaguchi (last single) 4th generation: Rika Ishikawa (last single), Hitomi Yoshizawa 5th generation: Ai Takahashi, Asami Konno, Makoto Ogawa, Risa Niigaki 6th generation: Miki Fujimoto, Eri Kamei, Sayumi Michishige, Reina Tanaka

Releasing hormone and Osaka Koi no Uta

Not to be confused with Release factor.

A releasing hormone or releasing factor' is a hormone whose main purpose is to control the release of other hormones. These are also called hypophysiotropic or hypothalamic hormones. The use of the term factor was employed for some time pending the establishment of the molecular structure of the hormones. When this had been fully established the hormones were referred to as releasing hormones. The main releasing hormones secreted by the hypothalamus are: Thyrotropin-releasing hormone (TRH), Corticotropin-releasing hormone (CRH), Gonadotropin-releasing hormone (GnRH), Growth hormone-releasing hormone (GHRH),

Two other factors are also classed as releasing hormones, although they in fact inhibit pituitary hormone release Somatostatin, Dopamine.

For example, TRH is released from the hypothalamus in response to low levels of secretion of thyroid stimulating hormone (TSH) from the pituitary gland. The TSH in turn is under feedback control by the thyroid hormones T4 and T3. When the levels of TSH are too high, they feed back on the brain to shut down the secretion of TRH. Synthetic TRH is also used by physicians as a test of TSH reserve in the pituitary gland as it should stimulate the release of TSH and prolactin from this gland.

Releasing hormones are sometimes known as liberins. For example, TRH may be known as thyroliberin. Inhibiting hormones may be known as statins. For example, dopamine (which inhibits prolactin release) may be called prolactostatin.

Contents 1 Mechanism 2 Notable researchers 3 See also 4 References

Mechanism

Releasing hormones increase (or, in case of inhibitory factors, decrease) the intracellular concentration of calcium (Ca2+), resulting in vesicle fusion of the respective primary hormone.

For GnRH, TRH and GHRH the increase in Ca2+ is achieved by the releasing hormone coupling and activating G protein coupled receptors coupled to the Gq alpha subunit, activating the IP3/DAG pathway to increase Ca2+. For GHRH, however, this is a minor pathway, the main one being the cAMP dependent pathway. Notable researchers

Roger Guillemin and Andrew W. Schally were awarded the Nobel Prize in Physiology and Medicine in 1977 for their contributions to understanding "the peptide hormone production of the brain"; these scientists independently first isolated TRH and GnRH and then identified their structures. See also Hormone Neuroendocrinology
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